Women represent nearly two-thirds of Alzheimer’s diagnoses. New research links hormonal milestones, menopause timing, and gaps in inclusive studies to risk.
From Loss to Urgency
After Sonia Elizabeth Cox’s Alzheimer’s diagnosis at 64, her family witnessed swift memory decline. Her daughter, Angeleta, became her primary caregiver, illustrating the devastating personal impact of dementia—but also the urgency to understand why women are disproportionately affected.
More Than Just Longevity
Statistics Canada shows women make up nearly two-thirds of people with Alzheimer’s in the country—not solely because they tend to live longer. Leading researchers are now looking at gender-specific biological and social factors that contribute to women’s higher Alzheimer’s rates. Age remains a factor, but it’s no longer the whole story.
Hormonal Milestones and Memory
Studies—including those using the UK Biobank—suggest that women with longer reproductive periods and one to three children may face lower Alzheimer’s risk. Conversely, women who experience premature (under 40) or early menopause (ages 40–44), or have ovaries removed before age 50, may face elevated risk. Estrogen treatments could offer neuroprotective benefits, according to experts.
Shaping Canadian Research Focus
Canadian scientists like Gillian Einstein and Natasha Rajah are championing research that includes sex, gender, and diversity. Rajah’s BHAMM study uses brain scans and blood markers to explore whether mid-life and menopause stages mark early Alzheimer’s signs. Their work aims to inform early detection and tailored care strategies.
Bridging Gaps, Nurturing Awareness
For families like the Coxes, this shift in understanding is deeply personal. Angeleta Cox chose not to undergo a hysterectomy affecting her hormonal trajectory after witnessing her mother’s condition—and now shares that insight across communities. “When it impacts women, it impacts families,” she says.
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